Synthesis vs destruction - For chemical bonds to form there needs to
be an external source of energy. Unfortunately, the same energy that
creates the bonds is much more likely to destroy them.
In the famous Miller experiment (1953) that synthesized amino acids,
a cold trap is used to selectively isolate the reaction products.
Without this, the would be no products.
This poses a challenge to simplistic early earth schemes where
lightning simply strikes a primitive ocean. Where is the "trap" in
such an ocean?
Also, the creation of amino acids by a chemist in a laboratory
is still much different from forming self-replicating life.
This point has not escaped the attention of evolutionists.
"The physical chemist, guided by the proved principles of chemical
thermodynamics and kinetics, cannot offer any encouragement to the
biochemist, who needs an ocean full of organic compounds to form even
lifeless coacervates [blobs]"
(D. E. Hull, Nature, 186, 693 1960)(Gish 1972, 13)