One approach (Oparin's Coacervate Theory) is to try to construct coacervates (large blobs of colloidal particles) from molecules. Unfortunately, this merely holds together random molecules by electrostatic chemical bonds. (Gish 1972, 27).
Another scheme uses microspheres (Fox's Proteinoid Microsphere Theory) by the pyrocondensation of amino acids. But these are only random polymers of amino acids that are inherently unstable. There are no energy-utilizing systems, no replicating systems, etc. (Gish 1972, 30)
A biological system is more than a collection of molecules thrown together - these blobs have to be able to do something, they have to act as little machines with input and output related to some greater purpose in the cell. How a biological system could arise still remains in the realm of "science fiction".
References: Gish 1972 Gish 1984TContinue with: Origin of Life: the Living Cell